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ISO 45001:2018 offers substantial advantages to those who adhere to it. No matter the size or industry of the organization, whether it be a small business, large organization, or even a non-profit, charity, academic institution, or governmental department, the standard is intended to be applicable to any organization and its requirements to be incorporated into any management system. A systematic approach to managing health and safety will be advantageous for the organization's employees as well as for the general public. In the end, safety and good health are profitable.

According to this standard, the following factors are necessary for effective health and safety management:
Top or senior management's ability to lead and dedication;
Encouraging an organization-wide culture of safety and wellness;
Identification of risks and risk management; Participation of employees and/or other representatives in the OH&S Management System;
The distribution of the required resources;
Incorporating the health and safety management system into relevant workflows;
Alignment of the organization's health and safety policy with its strategic goals;
The health and safety management system is continually assessed and watched over to improve performance.